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Gene: TTC4 (tetratricopeptide repeat domain 4) Pan paniscus

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Symbol:

TTC4

Name:

tetratricopeptide repeat domain 4

RGD ID:

11683482

Description:

ENCODES a protein that exhibits Hsp70 protein binding (inferred); Hsp90 protein binding (inferred); INVOLVED IN defense response to virus (inferred); innate immune response (inferred); protein folding (inferred); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleus (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

tetratricopeptide repeat protein 4

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	172,092,298 - 172,118,317 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	171,233,183 - 171,259,181 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	53,992,074 - 54,018,030 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	55,581,396 - 55,607,646 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	55,581,396 - 55,607,646 (+)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

defense response to virus (IEA)

innate immune response (IEA)

protein folding (IEA)

Cellular Component

cytoplasm (IEA)

cytosol (IEA)

nucleus (IEA)

Molecular Function

Hsp70 protein binding (IEA)

Hsp90 protein binding (IEA)

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

TTC4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	172,092,298 - 172,118,317 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	171,233,183 - 171,259,181 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	53,992,074 - 54,018,030 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	55,581,396 - 55,607,646 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	55,581,396 - 55,607,646 (+)	Ensembl	panpan1.1		panPan2

TTC4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	54,715,861 - 54,742,657 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	54,715,861 - 54,742,657 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	55,181,534 - 55,208,330 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	54,954,117 - 54,980,569 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	54,893,576 - 54,920,001	NCBI
Celera	1	53,469,087 - 53,495,920 (+)	NCBI		Celera
Cytogenetic Map	1	p32.3	NCBI
HuRef	1	53,295,157 - 53,322,784 (+)	NCBI		HuRef
CHM1_1	1	55,296,858 - 55,323,691 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	54,596,115 - 54,622,890 (+)	NCBI		T2T-CHM13v2.0

Ttc4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	106,514,952 - 106,536,188 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	106,519,453 - 106,536,141 (-)	Ensembl		GRCm39 Ensembl
GRCm38	4	106,656,806 - 106,679,002 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	106,662,256 - 106,678,944 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	106,334,413 - 106,351,549 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	106,160,188 - 106,176,814 (-)	NCBI		MGSCv36	mm8
Celera	4	105,024,628 - 105,041,763 (-)	NCBI		Celera
Cytogenetic Map	4	C7	NCBI
cM Map	4	49.68	NCBI

Ttc4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	126,673,535 - 126,691,203 (-)	NCBI		GRCr8
mRatBN7.2	5	121,444,712 - 121,462,381 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	121,445,740 - 121,462,287 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	124,063,423 - 124,081,060 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	125,786,475 - 125,804,112 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	125,837,736 - 125,855,373 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	126,264,758 - 126,282,431 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	126,264,105 - 126,282,385 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	130,109,141 - 130,127,441 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	127,746,728 - 127,756,081 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	127,751,976 - 127,761,307 (-)	NCBI
Celera	5	120,201,186 - 120,210,532 (-)	NCBI		Celera
Cytogenetic Map	5	q34	NCBI

Ttc4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955464	4,629,932 - 4,669,333 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955464	4,629,061 - 4,669,054 (-)	NCBI	ChiLan1.0	ChiLan1.0

TTC4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	54,406,216 - 54,431,742 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	54,407,287 - 54,431,687 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	54,475,489 - 54,500,962 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	54,594,550 - 54,619,793 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	54,590,047 - 54,619,822 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	54,590,989 - 54,616,219 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	54,481,088 - 54,506,291 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	54,870,103 - 54,895,370 (-)	NCBI		UU_Cfam_GSD_1.0

Ttc4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	68,857,176 - 68,884,945 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936522	6,529,122 - 6,559,292 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936522	6,525,887 - 6,559,147 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TTC4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	157,616,502 - 157,651,655 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	157,616,499 - 157,651,676 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	145,680,005 - 145,715,186 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TTC4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	78,193,416 - 78,222,430 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	78,190,147 - 78,222,349 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666033	39,060,341 - 39,088,741 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ttc4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624862	5,097,343 - 5,126,537 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624862	5,097,233 - 5,126,555 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003814995	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034965860	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000036669 ⟹ ENSPPAP00000013994

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	1	55,581,396 - 55,607,646 (+)	Ensembl

RefSeq Acc Id:

XM_003814995 ⟹ XP_003815043

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	1	172,092,298 - 172,118,317 (-)	NCBI
NHGRI_mPanPan1	1	171,233,183 - 171,259,181 (-)	NCBI
Mhudiblu_PPA_v0	1	53,992,075 - 54,018,030 (+)	NCBI
PanPan1.1	1	55,581,396 - 55,607,646 (+)	NCBI

Sequence:

show sequence

GAGGGAAGGGCACCCGCGCCGCCGGAAGGAGCCGCTCGCTTCACGGCGCTGGGACCCGGGCTGG
AAGGCAGGGCATCAGCTATGGAACAACCTGGGCAGGATCCCACCTCAGACGACGTCATGGACTC
TTTCCTGGAAAAGTTCCAGAGCCACCCTTACCGTGGCGGCTTTCATGAGGACCAGTGGGAGAAG
GAATTTGAAAAGGTCCCCCTATTTATGACGAGAGCGCCATCAGAAATTGATCCCAGGGAGAATC
CTGACTTGGCTTGTCTCCAGTCAATTATTTTTGATGAGGAGCGTTCTCCAGAAGAACAGGCCAA
GACCTATAAAGATGAGGGCAATGATTACTTTAAAGAAAAAGACTACAAGAAAGCTGTAATTTCA
TACACTGAAGGCTTAAAGAAGAAATGTGCAGATCCTGATTTGAATGCTGTCCTTTATACCAACC
GGGCAGCAGCACAGTACTATCTGGGCAATTTTCGTTCTGCTCTCAATGACGTGACAGCTGCCAG
AAAGCTAAAACCCTGCCACCTCAAAGCAATAATAAGAGGTGCCTTATGCCATCTGGAACTGAAA
CACTTTGCTGAGGCCGTGAACTGGTGTGATGAGGGACTGCAAATAGATGCCAAAGAGAAGAAGC
TTCTGGAAATGAGGGCTAAAGCAGACAAGCTGAAGCGAATTGAACAGAGGGATGTGAGGAAAGC
CAACCTGAAAGAAAAGAAGGAGAGGAATCAGAATGAGGCTTTACTCCAGGCCATCAAGGCTAGG
AATATCAGGCTCTCAGAAACTGCCTGTGAGGATGAAGATTCAGCCTCAGAAGGTCTAGGTGAGC
TTTTCCTGGATGGACTCAGCACTGAGAACCCCCATGGAGCCAGGCTGAGTCTAGATGGCCAGGG
CAGGCTGAGCTGGCCTGTGCTCTTTCTGTACCCAGAGTATGCCCAGTCGGACTTCATCTCTGCT
TTTCATGAGGACTCCAGGTTTATTGATCATCTGATGGTGATGTTTGGTGAAACACCCTCTTGGG
ACCTAGAGCAAAAATATTGCCCTGATAATTTGGAGGTCTACTTTGAGGATGAGGACAGGGCAGA
ACTATACCGGGTGCCTGCCAAGAGCACCTTGCTACAGGTTCTACAGCACCAGAGGTACTTTGTA
AAAGCCCTGACACCAGCATTTTTGGTCTGTGTAGGATCCTCTCCTTTTTGCAAGAATTATCTCC
GGGGGAGAAAGGTGTACCAGATACGATGACTAAGCCAGGGCCCCTGGATCTGCTCCCTCACCCT
CCTCTGCTGGGAACCTAGCACACCTGAATCAGCTGGACATACTGCTGGAGTCCAGTGCTTTCTT
TCCGTCACCCTGGGGATAGTCCTTCCTGGCATCGTGGTCGGGGAGGAGCCTCTGGCTTCCCTAA
ACTGCAGCCTCTCTGGCTGGTCTTCCTCAGTTGATATAAAACTCTGGGTCTTGGCCATGATGTC
CTTGGACTCCATCGCTAAAGGGACCATCTGCTGCAGTTACCACAGCAACTGACCTGAGCGGCAC
CCTGGTCTGTGGAGATGGACTCAGGATCCAGTGACATGATTCTGAACTTTTGTGGAGTTTGACA
TCTTAGAGAAGCTACCCCTCAAACTGCACATCTACACACAAACAAACAATGCATAGGATTCCAA
GGCTTTAAAGCTGAGAGACCCTGGCCTCAAGTTATTTCATGCGCACAGAGGGAAGCCATGCGGG
GTTGCTGAAGATGCCTTGAGGTGAAATGGGTGCAGGAAAGCCACATCTTGCTCTGCATTTATAA
AGACCGTACAAACTGAGATCCTTGGTACCCCTAAAAAGATTGCCAATTTTCTTCATCTTTGCCA
TATGGAGGACTGTGACAGACTTGGACAGTGGCCTCTTGAGTTCCTCTGCAGTTTTGACATTTAG
GATTTTGTGTCTTTTAAACTGGAAAATCTTCTAGCATGTTGGGTTGTTATAGAGTATATTTTTG
TCTGCAGCTGTTTGTTGCCCTGTTCCTAAGAGGAGTTTATCCATCCTGACCTGTAGCTGTGTGA
CTTCTTGCAGTGCCCCCACCCCATCCCCCCGGGAGAGTGTACTTCCCTGCTCCCGATGCAGAGG
GATATGCGCAGGCATGAGCTGTCCTGCGTCTGACAGAAGCCTGAAGAGTCATGTGTGGTTGGCC
TGTGCTCTTCCCTCTGCTGTGAGAACACATTTCCCACAGAGGAGCCGTTCCATGGAGCCGAGCT
ACAGCAGCTGGCCTGCAGCCACTGAGTGTCACAGCAATGAGAGAGCAATGTTTGCTGTAGTAAG
CAGTGAGATTTAGGGGTTGGTTGTTACTATAGCAGAGCTAATACATCAGTAAACTGAA

hide sequence

RefSeq Acc Id:

XM_034965860 ⟹ XP_034821751

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	1	172,092,298 - 172,118,256 (-)	NCBI
NHGRI_mPanPan1	1	171,233,183 - 171,259,143 (-)	NCBI
Mhudiblu_PPA_v0	1	53,992,074 - 54,018,030 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_003815043	(Get FASTA)	NCBI Sequence Viewer
	XP_034821751	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000013538.1
	ENSPPAP00000013994.1

RefSeq Acc Id:	XP_003815043 ⟸ XM_003814995
- Peptide Label:	isoform X1
- UniProtKB:	A0A2R9A9P0 (UniProtKB/TrEMBL), A0A2R9ADF9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MEQPGQDPTSDDVMDSFLEKFQSHPYRGGFHEDQWEKEFEKVPLFMTRAPSEIDPRENPDLACL QSIIFDEERSPEEQAKTYKDEGNDYFKEKDYKKAVISYTEGLKKKCADPDLNAVLYTNRAAAQY YLGNFRSALNDVTAARKLKPCHLKAIIRGALCHLELKHFAEAVNWCDEGLQIDAKEKKLLEMRA KADKLKRIEQRDVRKANLKEKKERNQNEALLQAIKARNIRLSETACEDEDSASEGLGELFLDGL STENPHGARLSLDGQGRLSWPVLFLYPEYAQSDFISAFHEDSRFIDHLMVMFGETPSWDLEQKY CPDNLEVYFEDEDRAELYRVPAKSTLLQVLQHQRYFVKALTPAFLVCVGSSPFCKNYLRGRKVY QIR hide sequence

RefSeq Acc Id:	XP_034821751 ⟸ XM_034965860
- Peptide Label:	isoform X2

Ensembl Acc Id:

ENSPPAP00000013994 ⟸ ENSPPAT00000036669

Protein Domains

Cns1/TTC4 wheel

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000029935	UniProtKB/TrEMBL
	ENSPPAG00000030150	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000036210.1	UniProtKB/TrEMBL
	ENSPPAT00000036669.1	UniProtKB/TrEMBL
Gene3D-CATH	1.25.40.10	UniProtKB/TrEMBL
InterPro	Csn1/TTC4_wheel	UniProtKB/TrEMBL
	TPR-like_helical_dom_sf	UniProtKB/TrEMBL
	TPR_repeat	UniProtKB/TrEMBL
KEGG Report	pps:100976105	UniProtKB/TrEMBL
NCBI Gene	TTC4	ENTREZGENE
PANTHER	TETRATRICOPEPTIDE REPEAT PROTEIN 4	UniProtKB/TrEMBL
	TETRATRICOPEPTIDE REPEAT PROTEIN 4	UniProtKB/TrEMBL
	WHEEL DOMAIN-CONTAINING PROTEIN	UniProtKB/TrEMBL
Pfam	Wheel	UniProtKB/TrEMBL
SMART	TPR	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48452	UniProtKB/TrEMBL
UniProt	A0A2R9A9P0	ENTREZGENE, UniProtKB/TrEMBL
	A0A2R9ADF9	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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