Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619809
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ntn1
Name: netrin 1
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ntn1decreases expressionISONtn1 (Mus musculus)6480464CTDStreptozocin results in decreased expression of NTN1 proteinPMID:29059224
Ntn1multiple interactionsISONtn1 (Mus musculus)6480464CTD[NTN1 protein co-treated with Streptozocin] results in increased expression of ARG1 protein; NTN1 protein inhibits the reaction [Streptozocin results in increased cleavage of CASP3 protein]; NTN1 protein inhibits the reaction [Streptozocin results in increased expression of CDKN2A mRNA]; NTN1 protein inhibits the reaction [Streptozocin results in increased expression of CDKN2A protein]; NTN1 protein inhibits the reaction [Streptozocin results in increased expression of PTGS2 protein]; NTN1 protein inhibits the reaction [Streptozocin results in increased expression of RELA protein]; NTN1 protein inhibits the reaction [Streptozocin results in increased expression of TRP53 mRNA]; NTN1 protein promotes the reaction [Streptozocin results in increased expression of DCC mRNA]; NTN1 protein promotes the reaction [Streptozocin results in increased expression of DCC protein]; Streptozocin promotes the reaction [NTN1 protein results in increased phosphorylation of MAPK1 protein]; Streptozocin promotes the reaction [NTN1 protein results in increased phosphorylation of MAPK3 protein]PMID:29059224
Go Back to source page   Continue to Ontology report