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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10215
Species: Mus musculus
RGD Object: Gene
Symbol: Atp7a
Name: ATPase, Cu++ transporting, alpha polypeptide
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Atp7adecreases expressionEXP 6480464CTDStreptozocin results in decreased expression of ATP7A proteinPMID:23884884
Atp7amultiple interactionsEXP 6480464CTDATP7A gene mutant form promotes the reaction [Streptozocin results in increased chemical synthesis of Superoxides]; ATP7A protein inhibits the reaction [Streptozocin results in increased chemical synthesis of Superoxides]; INS protein inhibits the reaction [Streptozocin results in decreased expression of ATP7A protein]PMID:23884884
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