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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736957
Species: Mus musculus
RGD Object: Gene
Symbol: Smad2
Name: SMAD family member 2
Acc ID: CHEBI:9150
Term: simvastatin
Definition: A member of the class of hexahydronaphthalenes that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug.
Chemical ID: MESH:D019821
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Smad2increases expressionEXP 6480464CTDSimvastatin results in increased expression of SMAD2 mRNAPMID:18310456
Smad2increases phosphorylationEXP 6480464CTDSimvastatin results in increased phosphorylation of SMAD2 proteinPMID:33034787
Smad2multiple interactionsEXP 6480464CTDFST protein inhibits the reaction [Simvastatin results in increased phosphorylation of SMAD2 protein]PMID:33034787
Smad2decreases phosphorylationISOSmad2 (Rattus norvegicus)6480464CTDSimvastatin results in decreased phosphorylation of SMAD2 proteinPMID:19659652
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