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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732558
Species: Mus musculus
RGD Object: Gene
Symbol: Vdac1
Name: voltage-dependent anion channel 1
Acc ID: CHEBI:88217
Term: N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine
Definition: An N-substituted diamine that is ethylenediamine in which the four amino hydrogens are replaced by 2-pyridylmethyl groups.
Chemical ID: MESH:C044387
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vdac1decreases expressionISOVdac1 (Rattus norvegicus)6480464CTDN,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of VDAC1 mRNAPMID:21605504
Vdac1increases expressionISOVdac1 (Rattus norvegicus)6480464CTDN,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of VDAC1 proteinPMID:21605504
Vdac1multiple interactionsISOVdac1 (Rattus norvegicus)6480464CTDZinc Sulfate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of VDAC1 mRNA]; Zinc Sulfate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of VDAC1 protein]PMID:21605504
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