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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731579
Species: Homo sapiens
RGD Object: Gene
Symbol: HMGCR
Name: 3-hydroxy-3-methylglutaryl-CoA reductase
Acc ID: CHEBI:8228
Term: pioglitazone
Definition: A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.
Chemical ID: MESH:C060836
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HMGCRincreases expressionEXP 6480464CTDpioglitazone results in increased expression of HMGCR mRNAPMID:12044893
HMGCRdecreases expressionISOHmgcr (Mus musculus)6480464CTDpioglitazone results in decreased expression of HMGCR mRNAPMID:20503262
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