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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68556
Species: Homo sapiens
RGD Object: Gene
Symbol: CCND1
Name: cyclin D1
Acc ID: CHEBI:81763
Term: fludioxonil
Definition: A member of the class of benzodioxoles that is 2,2-difluoro-1,3-benzodioxole substituted at position 4 by a 3-cyanopyrrol-4-yl group. A fungicide seed treatment for control of a range of diseases including Fusarium, Rhizoctonia and Alternaria.
Chemical ID: MESH:C108339
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CCND1decreases expressionEXP 6480464CTDfludioxonil results in decreased expression of CCND1 mRNAPMID:23052036
CCND1increases expressionEXP 6480464CTDfludioxonil results in increased expression of CCND1 mRNA; fludioxonil results in increased expression of CCND1 proteinPMID:23436777 PMID:27539251
CCND1multiple interactionsEXP 6480464CTDESR1 protein affects the reaction [fludioxonil results in decreased expression of CCND1 mRNA]; Estradiol inhibits the reaction [fludioxonil results in increased expression of CCND1 mRNA]; fulvestrant inhibits the reaction [fludioxonil results in increased expression of CCND1 protein]PMID:23052036 PMID:23436777 PMID:27539251
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