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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2635
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fth1
Name: ferritin heavy chain 1
Acc ID: CHEBI:78492
Term: diallyl trisulfide
Definition: An organic trisulfide that is trisulfane in which both of the hydrogens are replaced by allyl groups. A component of the essential oil of garlic and a major component of the traditional Chinese medicine allitridium, it exhibits antifungal, antitumour and antioxidant activity
Chemical ID: MESH:C042577
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fth1increases expressionISOFTH1 (Homo sapiens)6480464CTDdiallyl trisulfide results in increased expression of FTH1 mRNAPMID:34995734
Fth1multiple interactionsISOFTH1 (Homo sapiens)6480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [diallyl trisulfide results in increased degradation of and results in decreased expression of FTH1 protein]; diallyl trisulfide results in increased degradation of and results in decreased expression of FTH1 proteinPMID:16707465
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