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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737482
Species: Homo sapiens
RGD Object: Gene
Symbol: BIRC5
Name: baculoviral IAP repeat containing 5
Acc ID: CHEBI:72564
Term: temozolomide
Definition: An imidazotetrazine that is 3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine which is substituted at positions 3, 4, and 8 by methyl, oxo, and carboxamide groups, respectively. A prodrug for MTIC (5-(3-methyltriaz-1-en-1-yl)-1H-imidazole-4-carboxamide, formed by spontaneous hydrolysis of temozolomide in the body), it is used as an oral alkylating agent for the treatment of newly diagnosed malignant glioblastoma multiforme (concomitantly with radiotherapy) and malignant melanoma.
Chemical ID: MESH:C047246
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
BIRC5decreases expressionEXP 6480464CTDtemozolomide results in decreased expression of BIRC5 proteinPMID:28122345
BIRC5increases expressionEXP 6480464CTDTemozolomide results in increased expression of BIRC5 mRNAPMID:31758290
BIRC5multiple interactionsEXP 6480464CTDXAF1 protein promotes the reaction [temozolomide results in decreased expression of BIRC5 protein]PMID:28122345
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