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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731002
Species: Homo sapiens
RGD Object: Gene
Symbol: CASP3
Name: caspase 3
Acc ID: CHEBI:65310
Term: triciribine
Definition: A nucleoside analogue in which the nucleobase portion is a 1,4,5,6,8-pentaazaacenaphthylene ring system substituted with an amino group at position 3, and a methyl group at position 5 and is bound to the beta-D-ribofuranosyl moiety by an N(1)-glycosidic linkage.
Chemical ID: MESH:C023764
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CASP3increases expressionEXP 6480464CTDtriciribine results in increased expression of CASP3 mRNAPMID:29117515
CASP3multiple interactionsEXP 6480464CTDtriciribine promotes the reaction [[epothilone A co-treated with Metformin] results in increased expression of CASP3 mRNA]PMID:29117515
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