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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733490
Species: Mus musculus
RGD Object: Gene
Symbol: Bard1
Name: BRCA1 associated RING domain 1
Acc ID: CHEBI:63618
Term: pravastatin
Definition: A carboxylic ester resulting from the formal condensation of (S)-2-methylbutyric acid with the hydroxy group adjacent to the ring junction of (3R,5R)-7-[(1S,2S,6S,8S,8aR)-6,8-dihydroxy-2-methyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid. Derived from microbial transformation of mevastatin, pravastatin is a reversible inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA). The sodium salt is used for lowering cholesterol and preventing cardiovascular disease. It is one of the lower potency statins, but has the advantage of fewer side effects compared with lovastatin and simvastatin.
Chemical ID: MESH:D017035
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bard1affects expressionEXP 6480464CTDPravastatin affects the expression of BARD1 mRNAPMID:27225895
Bard1decreases expressionISOBard1 (Rattus norvegicus)6480464CTDPravastatin results in decreased expression of BARD1 mRNAPMID:27225895
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