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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1315760
Species: Mus musculus
RGD Object: Gene
Symbol: Nfe2
Name: nuclear factor, erythroid derived 2
Acc ID: CHEBI:63618
Term: pravastatin
Definition: A carboxylic ester resulting from the formal condensation of (S)-2-methylbutyric acid with the hydroxy group adjacent to the ring junction of (3R,5R)-7-[(1S,2S,6S,8S,8aR)-6,8-dihydroxy-2-methyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid. Derived from microbial transformation of mevastatin, pravastatin is a reversible inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA). The sodium salt is used for lowering cholesterol and preventing cardiovascular disease. It is one of the lower potency statins, but has the advantage of fewer side effects compared with lovastatin and simvastatin.
Chemical ID: MESH:D017035
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfe2increases expressionEXP 6480464CTDPravastatin results in increased expression of NFE2 mRNAPMID:27225895
Nfe2increases expressionISONfe2 (Rattus norvegicus)6480464CTDPravastatin results in increased expression of NFE2 mRNAPMID:27225895
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