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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737596
Species: Homo sapiens
RGD Object: Gene
Symbol: RAF1
Name: Raf-1 proto-oncogene, serine/threonine kinase
Acc ID: CHEBI:63448
Term: PD173074
Definition: A member of the class of ureas that is 1-tert-butylurea in which one of the hydrogens attached to N(3) is substituted by a pyrido[2,3-d]pyrimidin-7-yl group, which is itself substituted at positions 2 and 6 by a 4-(diethylamino)butyl]amino group and a 3,5-dimethoxyphenyl group, respectively. It is a FGF/VEGF receptor tyrosine kinase inhibitor.
Chemical ID: MESH:C115711
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
RAF1decreases expressionEXP 6480464CTDPD 173074 results in decreased expression of RAF1 protein; PD 173074 results in decreased expression of RAF1 protein modified formPMID:27794399
RAF1multiple interactionsEXP 6480464CTD[Arsenic Trioxide co-treated with PD 173074] results in decreased expression of RAF1 protein; [Arsenic Trioxide co-treated with PD 173074] results in decreased expression of RAF1 protein modified form; [Arsenic Trioxide results in increased susceptibility to PD 173074] which results in decreased expression of RAF1 protein; [PD 173074 results in increased susceptibility to Arsenic Trioxide] which results in decreased expression of RAF1 protein; [PD 173074 results in increased susceptibility to Arsenic Trioxide] which results in decreased expression of RAF1 protein modified form; Arsenic Trioxide promotes the reaction [PD 173074 results in decreased expression of RAF1 protein modified form]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Arsenic Trioxide co-treated with PD 173074] results in decreased expression of RAF1 protein modified form]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Arsenic Trioxide co-treated with PD 173074] results in decreased expression of RAF1 protein]PMID:27794399
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