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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735203
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tbx3
Name: T-box transcription factor 3
Acc ID: CHEBI:63448
Term: PD173074
Definition: A member of the class of ureas that is 1-tert-butylurea in which one of the hydrogens attached to N(3) is substituted by a pyrido[2,3-d]pyrimidin-7-yl group, which is itself substituted at positions 2 and 6 by a 4-(diethylamino)butyl]amino group and a 3,5-dimethoxyphenyl group, respectively. It is a FGF/VEGF receptor tyrosine kinase inhibitor.
Chemical ID: MESH:C115711
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tbx3multiple interactionsISOTBX3 (Homo sapiens)6480464CTDPD 173074 inhibits the reaction [afimoxifene results in increased expression of TBX3 protein]; PD 173074 inhibits the reaction [Estrogens results in increased expression of TBX3 protein]PMID:21098263
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