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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1604306
Species: Homo sapiens
RGD Object: Gene
Symbol: VKORC1
Name: vitamin K epoxide reductase complex subunit 1
Acc ID: CHEBI:53766
Term: acenocoumarol
Definition: A hydroxycoumarin that is warfarin in which the hydrogen at position 4 of the phenyl substituent is replaced by a nitro group.
Chemical ID: MESH:D000074
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
VKORC1affects response to substanceEXP 6480464CTDVKORC1 gene polymorphism affects the susceptibility to Acenocoumarol; VKORC1 gene SNP affects the susceptibility to Acenocoumarol; VKORC1 intron SNP affects the susceptibility to Acenocoumarol; VKORC1 polymorphism affects the susceptibility to Acenocoumarol; VKORC1 protein polymorphism affects the susceptibility to AcenocoumarolPMID:16201835 PMID:16611310 PMID:16869821 PMID:18698879 PMID:19578179 PMID:25042728 PMID:25866574 PMID:26757860 PMID:28867752
VKORC1decreases activityEXP 6480464CTDAcenocoumarol results in decreased activity of VKORC1 proteinPMID:29581108
VKORC1decreases response to substanceEXP 6480464CTDVKORC1 promoter polymorphism results in decreased susceptibility to Acenocoumarol; VKORC1 protein polymorphism results in decreased susceptibility to AcenocoumarolPMID:17036862 PMID:19875892
VKORC1increases response to substanceEXP 6480464CTDVKORC1 protein results in increased susceptibility to AcenocoumarolPMID:16869821
VKORC1multiple interactionsEXP 6480464CTDAcenocoumarol inhibits the reaction [VKORC1 protein results in increased reduction of Vitamin K 1]PMID:29581108
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