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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1351542
Species: Homo sapiens
RGD Object: Gene
Symbol: UGT2B7
Name: UDP glucuronosyltransferase family 2 member B7
Acc ID: CHEBI:5004
Term: fenoprofen
Definition: A monocarboxylic acid that is propanoic acid in which one of the hydrogens at position 2 is substituted by a 3-phenoxyphenyl group. A non-steroidal anti-inflammatory drug, the dihydrate form of the calcium salt is used for the management of mild to moderate pain and for the relief of pain and inflammation associated with disorders such as arthritis. It is pharmacologically similar to aspirin, but causes less gastrointestinal bleeding.
Chemical ID: MESH:D005279
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
UGT2B7increases glucuronidationEXP 6480464CTDUGT2B7 protein alternative form results in increased glucuronidation of Fenoprofen; UGT2B7 protein results in increased glucuronidation of FenoprofenPMID:8423545 PMID:8517101
UGT2B7multiple interactionsEXP 6480464CTDFenoprofen inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; Fenoprofen inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]PMID:19740398
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