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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:fenoprofen
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Accession:CHEBI:5004 term browser browse the term
Definition:A monocarboxylic acid that is propanoic acid in which one of the hydrogens at position 2 is substituted by a 3-phenoxyphenyl group. A non-steroidal anti-inflammatory drug, the dihydrate form of the calcium salt is used for the management of mild to moderate pain and for the relief of pain and inflammation associated with disorders such as arthritis. It is pharmacologically similar to aspirin, but causes less gastrointestinal bleeding.
Synonyms:exact_synonym: 2-(3-phenoxyphenyl)propanoic acid
 related_synonym: (+-)-m-phenoxyhydratropic acid;   2-(3-phenoxyphenyl)propionic acid;   2-(m-phenoxyphenyl)propionic acid;   Formula=C15H14O3;   InChI=1S/C15H14O3/c1-11(15(16)17)12-6-5-9-14(10-12)18-13-7-3-2-4-8-13/h2-11H,1H3,(H,16,17);   InChIKey=RDJGLLICXDHJDY-UHFFFAOYSA-N;   SMILES=CC(C(O)=O)c1cccc(Oc2ccccc2)c1;   alpha-(m-phenoxyphenyl)propionic acid;   alpha-methyl-3-phenoxybenzeneacetic acid;   fenoprofene;   fenoprofeno;   fenoprofenum
 alt_id: CHEBI:355534
 xref: CAS:31879-05-7;   DrugBank:DB00573;   Drug_Central:1154;   KEGG:C06997;   KEGG:D02350
 xref_mesh: MESH:D005279
 xref: PMID:21328296;   PMID:21342694;   PMID:25554116;   PMID:28166217;   PMID:30168706;   PMID:4616811;   Patent:US3600437;   Reaxys:2118687;   Wikipedia:_Fenoprofen
 cyclic_relationship: is_conjugate_acid_of CHEBI:60566


show annotations for term's descendants           Sort by:
fenoprofen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACSL1 acyl-CoA synthetase long chain family member 1 increases metabolic processing ISO ACSL1 protein results in increased metabolism of Fenoprofen CTD PMID:10725307 NCBI chr 4:184,755,595...184,826,594
Ensembl chr 4:184,755,595...184,826,818 		JBrowse link
G ACSL6 acyl-CoA synthetase long chain family member 6 increases metabolic processing ISO ACSL6 protein results in increased metabolism of Fenoprofen CTD PMID:10725307 NCBI chr 5:131,949,973...132,012,213
Ensembl chr 5:131,949,973...132,012,243 		JBrowse link
G ALB albumin multiple interactions
affects binding		 EXP Fenoprofen inhibits the reaction [Valproic Acid binds to ALB protein]; Ibuprofen inhibits the reaction [Fenoprofen binds to ALB protein]; Palmitic Acid inhibits the reaction [Fenoprofen binds to ALB protein] CTD PMID:62049 PMID:8946661 PMID:9353694 PMID:9470966 PMID:19596536 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482 		JBrowse link
G DHRS11 dehydrogenase/reductase 11 decreases activity EXP Fenoprofen results in decreased activity of DHRS11 protein CTD PMID:30926317 NCBI chr17:36,591,879...36,600,804
Ensembl chr17:36,591,879...36,600,804 		JBrowse link
G HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 affects expression EXP Fenoprofen affects the expression of HLA-DPA1 mRNA CTD PMID:25811541 NCBI chr 6:33,064,569...33,080,748
Ensembl chr 6:33,064,569...33,080,775 		JBrowse link
G HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 affects expression EXP Fenoprofen affects the expression of HLA-DQB1 mRNA CTD PMID:25811541 NCBI chr 6:32,659,467...32,666,657
Ensembl chr 6:32,659,467...32,668,383 		JBrowse link
G HLA-DRB6 major histocompatibility complex, class II, DR beta 6 (pseudogene) affects expression EXP Fenoprofen affects the expression of HLA-DRB6 mRNA CTD PMID:25811541 NCBI chr 6:32,552,713...32,560,002
Ensembl chr 6:32,552,713...32,560,022
Ensembl chr 6:32,552,713...32,560,022 		JBrowse link
G HPGD 15-hydroxyprostaglandin dehydrogenase multiple interactions EXP [Fenoprofen co-treated with NAD] binds to HPGD protein CTD PMID:25526675 NCBI chr 4:174,490,175...174,522,893
Ensembl chr 4:174,490,175...174,523,154 		JBrowse link
G NGFR nerve growth factor receptor increases expression EXP Fenoprofen results in increased expression of NGFR protein CTD PMID:17409433 NCBI chr17:49,495,293...49,515,008
Ensembl chr17:49,495,293...49,515,008 		JBrowse link
G PPARA peroxisome proliferator activated receptor alpha multiple interactions EXP Fenoprofen binds to and results in increased activity of PPARA protein CTD PMID:9013583 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,755 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions EXP Fenoprofen binds to and results in increased activity of PPARG protein CTD PMID:9013583 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356 		JBrowse link
G PTGR1 prostaglandin reductase 1 affects activity EXP Fenoprofen affects the activity of PTGR1 protein CTD PMID:25619643 NCBI chr 9:111,549,722...111,599,647
Ensembl chr 9:111,549,722...111,599,893 		JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions ISO Fenoprofen inhibits the reaction [rolafagrel results in decreased expression of TGFB1 mRNA] CTD PMID:8877289 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922 		JBrowse link
G TNF tumor necrosis factor multiple interactions ISO [Fenoprofen co-treated with Lipopolysaccharides] results in increased secretion of TNF protein CTD PMID:17328244 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G UGT1A10 UDP glucuronosyltransferase family 1 member A10 increases glucuronidation EXP UGT1A10 protein results in increased glucuronidation of Fenoprofen CTD PMID:15117964 NCBI chr 2:233,636,448...233,773,300
Ensembl chr 2:233,636,448...233,773,300 		JBrowse link
G UGT1A3 UDP glucuronosyltransferase family 1 member A3 increases glucuronidation EXP UGT1A3 protein results in increased glucuronidation of Fenoprofen CTD PMID:15117964 NCBI chr 2:233,729,042...233,773,300
Ensembl chr 2:233,729,042...233,773,300 		JBrowse link
G UGT1A7 UDP glucuronosyltransferase family 1 member A7 increases glucuronidation EXP UGT1A7 protein results in increased glucuronidation of Fenoprofen CTD PMID:15117964 NCBI chr 2:233,681,901...233,773,300
Ensembl chr 2:233,681,901...233,773,300 		JBrowse link
G UGT1A8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation EXP UGT1A8 protein results in increased glucuronidation of Fenoprofen CTD PMID:15117964 NCBI chr 2:233,617,633...233,773,300
Ensembl chr 2:233,617,633...233,773,300 		JBrowse link
G UGT2B7 UDP glucuronosyltransferase family 2 member B7 multiple interactions
increases glucuronidation		 EXP Fenoprofen inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; Fenoprofen inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]
UGT2B7 protein alternative form results in increased glucuronidation of Fenoprofen; UGT2B7 protein results in increased glucuronidation of Fenoprofen		 CTD PMID:8423545 PMID:8517101 PMID:19740398 NCBI chr 4:69,051,375...69,112,987
Ensembl chr 4:69,051,363...69,112,987 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26041
    role 25957
      application 25179
        anti-inflammatory agent 17811
          anti-inflammatory drug 15764
            non-steroidal anti-inflammatory drug 15009
              fenoprofen 19
Path 2
Term Annotations click to browse term
  CHEBI ontology 26041
    subatomic particle 26016
      composite particle 26016
        hadron 26016
          baryon 26016
            nucleon 26016
              atomic nucleus 26016
                atom 26016
                  main group element atom 25841
                    p-block element atom 25841
                      carbon group element atom 25441
                        carbon atom 25399
                          organic molecular entity 25399
                            heteroorganic entity 24773
                              organochalcogen compound 24384
                                organooxygen compound 24061
                                  carbon oxoacid 22757
                                    carboxylic acid 22737
                                      monocarboxylic acid 21735
                                        fenoprofen 19
paths to the root