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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3031
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Smad2
Name: SMAD family member 2
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Smad2decreases expressionISOSMAD2 (Homo sapiens)6480464CTDArsenic Trioxide results in decreased expression of SMAD2 mRNAPMID:25258189
Smad2increases expressionISOSMAD2 (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of SMAD2 mRNAPMID:32240679
Smad2multiple interactionsISOSMAD2 (Homo sapiens)6480464CTDArsenic Trioxide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]; RNF4 protein affects the reaction [Arsenic Trioxide results in increased expression of SMAD2 mRNA]; UBE2I protein affects the reaction [Arsenic Trioxide results in increased expression of SMAD2 mRNA]PMID:24762191 PMID:30317545 PMID:32240679
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