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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1350018
Species: Homo sapiens
RGD Object: Gene
Symbol: UGT1A1
Name: UDP glucuronosyltransferase family 1 member A1
Acc ID: CHEBI:47807
Term: sulforaphane
Definition: An isothiocyanate having a 4-(methylsulfinyl)butyl group attached to the nitrogen.
Chemical ID: MESH:C016766
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
UGT1A1decreases expressionEXP 6480464CTDsulforaphane results in decreased expression of UGT1A1 mRNAPMID:12949046
UGT1A1increases expressionEXP 6480464CTDsulforaphane results in increased expression of UGT1A1 mRNA; sulforaphane results in increased expression of UGT1A1 proteinPMID:12151360 PMID:12756216 PMID:12949046 PMID:15090468 PMID:15896333
UGT1A1multiple interactionsEXP 6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [sulforaphane results in increased expression of UGT1A1 mRNA]; [sulforaphane co-treated with Apigenin] results in increased expression of UGT1A1 mRNAPMID:15090468
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