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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621747
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gsr
Name: glutathione-disulfide reductase
Acc ID: CHEBI:45863
Term: paclitaxel
Definition: A tetracyclic diterpenoid isolated originally from the bark of the Pacific yew tree, Taxus brevifolia. It is a mitotic inhibitor used in cancer chemotherapy. Note that the use of the former generic name 'taxol' is now limited, as Taxol is a registered trade mark.
Chemical ID: MESH:D017239
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsrdecreases activityEXP 6480464CTDPaclitaxel results in decreased activity of GSR proteinPMID:37949423
Gsrdecreases expressionEXP 6480464CTDPaclitaxel results in decreased expression of GSR mRNAPMID:37949423
Gsrmultiple interactionsEXP 6480464CTDparthenolide inhibits the reaction [Paclitaxel results in decreased activity of GSR protein]; parthenolide inhibits the reaction [Paclitaxel results in decreased expression of GSR mRNA]PMID:37949423
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