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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1624100
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp2a4
Name: cytochrome P450, family 2, subfamily a, polypeptide 4
Acc ID: CHEBI:41922
Term: diethylstilbestrol
Definition: An olefinic compound that is trans-hex-3-ene in which the hydrogens at positions 3 and 4 have been replaced by p-hydroxyphenyl groups.
Chemical ID: MESH:D004054
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2a4increases expressionEXP 6480464CTDDiethylstilbestrol results in increased expression of CYP2A4 mRNAPMID:16452187 PMID:19665456
Cyp2a4multiple interactionsEXP 6480464CTD[Diethylstilbestrol co-treated with sodium arsenite] results in increased expression of CYP2A4 mRNA; sodium arsenite promotes the reaction [Diethylstilbestrol results in increased expression of CYP2A4 mRNA]PMID:16452187 PMID:19665456
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