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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1623277
Species: Mus musculus
RGD Object: Gene
Symbol: Svs4
Name: seminal vesicle secretory protein 4
Acc ID: CHEBI:41922
Term: diethylstilbestrol
Definition: An olefinic compound that is trans-hex-3-ene in which the hydrogens at positions 3 and 4 have been replaced by p-hydroxyphenyl groups.
Chemical ID: MESH:D004054
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Svs4affects methylationEXP 6480464CTDDiethylstilbestrol affects the methylation of SVS4 promoterPMID:24316720
Svs4decreases expressionEXP 6480464CTDDiethylstilbestrol results in decreased expression of SVS4 mRNA; Diethylstilbestrol results in decreased expression of SVS4 proteinPMID:22275727
Svs4multiple interactionsEXP 6480464CTDESR1 mutant form inhibits the reaction [Diethylstilbestrol affects the methylation of SVS4 promoter]; ESR1 protein affects the reaction [Diethylstilbestrol results in decreased expression of SVS4 mRNA]; ESR1 protein affects the reaction [Diethylstilbestrol results in decreased expression of SVS4 protein]; ESR2 protein affects the reaction [Diethylstilbestrol results in decreased expression of SVS4 mRNA]PMID:22275727 PMID:24316720
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