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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1347893
Species: Homo sapiens
RGD Object: Gene
Symbol: HSD3B1
Name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
Acc ID: CHEBI:41922
Term: diethylstilbestrol
Definition: An olefinic compound that is trans-hex-3-ene in which the hydrogens at positions 3 and 4 have been replaced by p-hydroxyphenyl groups.
Chemical ID: MESH:D004054
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HSD3B1decreases activityEXP 6480464CTDDiethylstilbestrol results in decreased activity of HSD3B1 proteinPMID:36374910
HSD3B1decreases expressionEXP 6480464CTDDiethylstilbestrol results in decreased expression of HSD3B1 mRNAPMID:12858341
HSD3B1decreases expressionISOHsd3b1 (Rattus norvegicus)6480464CTDDiethylstilbestrol results in decreased expression of HSD3B1 mRNAPMID:17229994 PMID:35605701
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