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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1346751
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP2B6
Name: cytochrome P450 family 2 subfamily B member 6
Acc ID: CHEBI:4042
Term: cypermethrin
Definition: A carboxylic ester resulting from the formal condensation between 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid and the alcoholic hydroxy group of hydroxy(3-phenoxyphenyl)acetonitrile.
Chemical ID: MESH:C017160
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP2B6increases activityEXP 6480464CTDcypermethrin results in increased activity of CYP2B6 proteinPMID:22310298
CYP2B6increases expressionEXP 6480464CTDcypermethrin results in increased expression of CYP2B6 mRNA; cypermethrin results in increased expression of CYP2B6 proteinPMID:15548381 PMID:22310298
CYP2B6decreases activityISOCyp2b10 (Mus musculus)6480464CTDcypermethrin results in decreased activity of CYP2B10 proteinPMID:18420780
CYP2B6increases expressionISOCyp2b10 (Mus musculus)6480464CTDcypermethrin results in increased expression of CYP2B10 mRNAPMID:31659573
CYP2B6multiple interactionsISOCyp2b10 (Mus musculus)6480464CTDSodium Selenite inhibits the reaction [cypermethrin results in increased expression of CYP2B10 mRNA]PMID:31659573
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