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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737155
Species: Homo sapiens
RGD Object: Gene
Symbol: FOXO1
Name: forkhead box O1
Acc ID: CHEBI:40303
Term: lovastatin
Definition: A fatty acid ester that is mevastatin carrying an additional methyl group on the carbobicyclic skeleton. It is used in as an anticholesteremic drug and has been found in fungal species such as Aspergillus terreus and Pleurotus ostreatus (oyster mushroom).
Chemical ID: MESH:D008148
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
FOXO1decreases phosphorylationISOFoxo1 (Mus musculus)6480464CTDLovastatin results in decreased phosphorylation of FOXO1 proteinPMID:33034787
FOXO1multiple interactionsISOFoxo1 (Mus musculus)6480464CTDLovastatin promotes the reaction [Fenofibrate results in increased expression of FOXO1 protein]PMID:33408297
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