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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3553
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Reln
Name: reelin
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Relndecreases expressionEXP 6480464CTDValproic Acid results in decreased expression of RELN mRNAPMID:29427782
Relnaffects expressionISORELN (Homo sapiens)6480464CTDValproic Acid affects the expression of RELN mRNAPMID:24849673 PMID:25979313
Relndecreases expressionISORELN (Homo sapiens)6480464CTDValproic Acid results in decreased expression of RELNPMID:25524013
Relndecreases methylationISOReln (Mus musculus)6480464CTDValproic Acid results in decreased methylation of RELN promoterPMID:20716949
Relnincreases expressionISORELN (Homo sapiens)6480464CTDValproic Acid results in increased expression of RELN mRNAPMID:23179753 PMID:24383497 PMID:26272509 PMID:28001369
Relnincreases methylationISORELN (Homo sapiens)6480464CTDValproic Acid results in increased methylation of RELN genePMID:29154799
Relnmultiple interactionsISORELN (Homo sapiens)6480464CTD[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RELN mRNAPMID:27188386
Relnmultiple interactionsISOReln (Mus musculus)6480464CTDValproic Acid inhibits the reaction [MECP2 binds to RELN promoter]; Valproic Acid inhibits the reaction [Methionine results in decreased expression of RELN protein]; Valproic Acid inhibits the reaction [Methionine results in increased methylation of RELN promoter]; Valproic Acid promotes the reaction [Clozapine results in decreased methylation of RELN promoter]; Valproic Acid promotes the reaction [Sulpiride results in decreased methylation of RELN promoter]PMID:15737665 PMID:16113080 PMID:18757738 PMID:19110320 PMID:20442623
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