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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735513
Species: Mus musculus
RGD Object: Gene
Symbol: Mcl1
Name: myeloid cell leukemia sequence 1
Acc ID: CHEBI:38319
Term: usnic acid
Definition: A member of the class of dibenzofurans that is dibenzo[b,d]furan-1(9bH)-one substituted by acetyl groups at positions 2 and 6, hydroxy groups at positions 3 and 7 and methyl groups at positions 8 and 9b.
Chemical ID: MESH:C073339
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mcl1decreases expressionISOMCL1 (Homo sapiens)6480464CTDusnic acid results in decreased expression of MCL1 proteinPMID:25078063
Mcl1multiple interactionsISOMCL1 (Homo sapiens)6480464CTD3-methyladenine promotes the reaction [usnic acid results in decreased expression of MCL1 protein]; Chloroquine promotes the reaction [usnic acid results in decreased expression of MCL1 protein]; pyrazolanthrone promotes the reaction [usnic acid results in decreased expression of MCL1 protein]PMID:25078063
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