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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62219
Species: Mus musculus
RGD Object: Gene
Symbol: Gjb1
Name: gap junction protein, beta 1
Acc ID: CHEBI:3750
Term: clofibrate
Definition: The ethyl ester of clofibric acid.
Chemical ID: MESH:D002994
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gjb1affects expressionISOGjb1 (Rattus norvegicus)6480464CTDClofibrate affects the expression of GJB1 mRNA; Clofibrate affects the expression of GJB1 proteinPMID:19483382 PMID:8968061
Gjb1decreases expressionISOGjb1 (Rattus norvegicus)6480464CTDClofibrate results in decreased expression of GJB1 proteinPMID:8597128
Gjb1multiple interactionsISOGjb1 (Rattus norvegicus)6480464CTD[Diethylnitrosamine co-treated with Clofibrate] results in increased expression of GJB1 proteinPMID:10550479
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