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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3796
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Syk
Name: spleen associated tyrosine kinase
Acc ID: CHEBI:3723
Term: citalopram
Definition: A racemate comprising equimolar amounts of (R)-citalopram and its enantiomer, escitalopram. It is used as an antidepressant, although only escitalopram is active.
Chemical ID: MESH:D015283
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sykmultiple interactionsISOSYK (Homo sapiens)6480464CTDCitalopram inhibits the reaction [convulxin promotes the reaction [FCER1G protein binds to SYK protein]]; Citalopram inhibits the reaction [convulxin promotes the reaction [SLC6A4 protein binds to SYK protein]]; Citalopram inhibits the reaction [convulxin results in increased phosphorylation of SYK protein]PMID:30592962
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