GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Epas1 | increases expression | EXP | | 6480464 | CTD | cobaltous chloride results in increased expression of EPAS1 protein | PMID:24503013 | Epas1 | affects localization | ISO | EPAS1 (Homo sapiens) | 6480464 | CTD | cobaltous chloride affects the localization of EPAS1 protein | PMID:21863063 | Epas1 | increases expression | ISO | Epas1 (Rattus norvegicus) | 6480464 | CTD | cobaltous chloride results in increased expression of EPAS1 protein | PMID:21558026 PMID:23545307 | Epas1 | increases expression | ISO | EPAS1 (Homo sapiens) | 6480464 | CTD | cobaltous chloride results in increased expression of EPAS1 protein | PMID:21036805 PMID:24503013 PMID:24790010 PMID:25805230 | Epas1 | increases response to substance | ISO | EPAS1 (Homo sapiens) | 6480464 | CTD | EPAS1 protein results in increased susceptibility to cobaltous chloride | PMID:25805230 | Epas1 | increases stability | ISO | EPAS1 (Homo sapiens) | 6480464 | CTD | cobaltous chloride results in increased stability of EPAS1 protein | PMID:18515279 | Epas1 | multiple interactions | ISO | Epas1 (Rattus norvegicus) | 6480464 | CTD | [AQP1 protein results in increased stability of EPAS1 protein] promotes the reaction [cobaltous chloride results in increased expression of EPAS1 protein]; [AQP3 protein results in increased stability of EPAS1 protein] promotes the reaction [cobaltous chloride results in increased expression of EPAS1 protein]; [AQP5 protein results in increased stability of EPAS1 protein] promotes the reaction [cobaltous chloride results in increased expression of EPAS1 protein] | PMID:23545307 | Epas1 | multiple interactions | ISO | EPAS1 (Homo sapiens) | 6480464 | CTD | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of EPAS1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of EPAS1 protein]; 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [cobaltous chloride results in increased expression of EPAS1 protein]; 6-O-carboxypropyl-alpha-tocotrienol inhibits the reaction [cobaltous chloride results in increased expression of EPAS1 protein]; [cobaltous chloride results in increased expression of EPAS1 protein] affects the reaction [EPAS1 protein binds to USF2 protein]; [cobaltous chloride results in increased expression of EPAS1 protein] which results in decreased expression of HIF1A protein; [cobaltous chloride results in increased expression of HIF1A protein] which results in decreased expression of EPAS1 protein; [EPAS1 protein results in increased susceptibility to cobaltous chloride] which results in increased expression of CD44 mRNA; [EPAS1 protein results in increased susceptibility to cobaltous chloride] which results in increased expression of NANOG mRNA; [EPAS1 protein results in increased susceptibility to cobaltous chloride] which results in increased expression of POU5F1 mRNA; [EPAS1 protein results in increased susceptibility to cobaltous chloride] which results in increased expression of PROM1 mRNA; [EPAS1 protein results in increased susceptibility to cobaltous chloride] which results in increased expression of SOX2 mRNA; Acetylcysteine inhibits the reaction [cobaltous chloride results in increased expression of EPAS1 protein]; cobaltous chloride results in increased expression of and affects the localization of EPAS1 protein; Cycloheximide inhibits the reaction [cobaltous chloride results in increased expression of EPAS1 protein]; Glutathione inhibits the reaction [cobaltous chloride results in increased expression of EPAS1 protein]; Indican inhibits the reaction [cobaltous chloride affects the localization of EPAS1 protein]; YES1 mutant form inhibits the reaction [cobaltous chloride results in increased expression of EPAS1 protein] | PMID:21863063 PMID:23958427 PMID:24790010 PMID:25805230 | | ||||||||||||||||||||||
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