GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | DNMT3A | increases expression | EXP | | 6480464 | CTD | Cadmium Chloride results in increased expression of DNMT3A mRNA; Cadmium Chloride results in increased expression of DNMT3A protein | PMID:22112500 PMID:25448810 PMID:34520792 | DNMT3A | multiple interactions | EXP | | 6480464 | CTD | [Cadmium Chloride results in increased activity of [DNMT1 protein co-treated with DNMT3A protein]] which results in decreased expression of ERCC1 mRNA; [Cadmium Chloride results in increased activity of [DNMT1 protein co-treated with DNMT3A protein]] which results in decreased expression of MSH2 mRNA; [Cadmium Chloride results in increased activity of [DNMT1 protein co-treated with DNMT3A protein]] which results in decreased expression of OGG1 mRNA; [Cadmium Chloride results in increased activity of [DNMT1 protein co-treated with DNMT3A protein]] which results in decreased expression of XRCC1 mRNA; [Cadmium Chloride results in increased activity of [DNMT1 protein co-treated with DNMT3A protein]] which results in increased methylation of ERCC1 promoter; [Cadmium Chloride results in increased activity of [DNMT1 protein co-treated with DNMT3A protein]] which results in increased methylation of MSH2 promoter; [Cadmium Chloride results in increased activity of [DNMT1 protein co-treated with DNMT3A protein]] which results in increased methylation of OGG1 promoter; [Cadmium Chloride results in increased activity of [DNMT1 protein co-treated with DNMT3A protein]] which results in increased methylation of XRCC1 promoter; Cadmium Chloride results in increased activity of and results in increased expression of DNMT3A protein; Decitabine inhibits the reaction [Cadmium Chloride results in increased expression of DNMT3A mRNA]; Decitabine inhibits the reaction [Cadmium Chloride results in increased expression of DNMT3A protein] | PMID:22112500 | DNMT3A | affects expression | ISO | Dnmt3a (Rattus norvegicus) | 6480464 | CTD | Cadmium Chloride affects the expression of DNMT3A mRNA; Cadmium Chloride affects the expression of DNMT3A protein | PMID:22957049 PMID:33865896 PMID:35525383 | DNMT3A | decreases expression | ISO | Dnmt3a (Rattus norvegicus) | 6480464 | CTD | Cadmium Chloride results in decreased expression of DNMT3A mRNA | PMID:33865896 | | ||||||||||||||||||||||
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