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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1343424
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP2A6
Name: cytochrome P450 family 2 subfamily A member 6
Acc ID: CHEBI:32692
Term: 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one
Definition: A nitrosamine that has formula C10H13N3O2.
Chemical ID: MESH:C016583
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP2A6affects metabolic processingEXP 6480464CTDCYP2A6 protein affects the metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanonePMID:12920169
CYP2A6increases activityEXP 6480464CTDCYP2A6 protein results in increased activity of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone; CYP2A6 results in increased activity of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanonePMID:15728263 PMID:21473878
CYP2A6increases hydroxylationEXP 6480464CTDCYP2A6 results in increased hydroxylation of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanonePMID:21473878
CYP2A6increases metabolic processingEXP 6480464CTDCYP2A6 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanonePMID:12115524 PMID:12214673 PMID:19018727
CYP2A6multiple interactionsEXP 6480464CTDCYB5A protein promotes the reaction [CYP2A6 protein results in increased activity of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone]; CYP2A6 protein affects the metabolism of and results in increased activity of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone; CYP2A6 protein results in increased metabolism of and results in increased activity of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanonePMID:11259349 PMID:11684323 PMID:11774366 PMID:11805739 PMID:15728263 PMID:16176798 PMID:17139156
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