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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733129
Species: Mus musculus
RGD Object: Gene
Symbol: Vim
Name: vimentin
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vimdecreases expressionEXP 6480464CTDBenzo(a)pyrene results in decreased expression of VIM mRNAPMID:19770486
Vimincreases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of VIM mRNAPMID:22228805 PMID:32417428
Vimaffects methylationISOVIM (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of VIM promoterPMID:27901495
Vimdecreases expressionISOVIM (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of VIM mRNA; Benzo(a)pyrene results in decreased expression of VIM proteinPMID:18247414 PMID:30659931 PMID:31255691
Vimincreases expressionISOVIM (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of VIM proteinPMID:31778776
Vimincreases methylationISOVIM (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of VIM 5' UTRPMID:27901495
Vimmultiple interactionsISOVIM (Homo sapiens)6480464CTD[Soot co-treated with Benzo(a)pyrene] results in increased expression of VIM protein modified form; LINC00673 affects the reaction [Benzo(a)pyrene results in increased expression of VIM protein]PMID:24464499 PMID:31778776
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