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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1359491
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pou5f1
Name: POU class 5 homeobox 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pou5f1increases methylationISOPOU5F1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of POU5F1 exonPMID:27901495
Pou5f1multiple interactionsISOPOU5F1 (Homo sapiens)6480464CTD[sodium arsenite co-treated with Benzo(a)pyrene] results in increased expression of POU5F1 protein; METTL3 protein promotes the reaction [[sodium arsenite co-treated with Benzo(a)pyrene] results in increased expression of POU5F1 protein]PMID:37972769
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