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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1316290
Species: Mus musculus
RGD Object: Gene
Symbol: Fyb1
Name: FYN binding protein 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fyb1decreases expressionEXP 6480464CTDBenzo(a)pyrene results in decreased expression of FYB1 mRNAPMID:21569818
Fyb1affects methylationISOFYB1 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of FYB1 5' UTR; Benzo(a)pyrene affects the methylation of FYB1 promoterPMID:27901495
Fyb1decreases expressionISOFYB1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of FYB1 mRNAPMID:20064835
Fyb1decreases methylationISOFYB1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of FYB1 exonPMID:27901495
Fyb1increases expressionISOFYB1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of FYB1 proteinPMID:32717239
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