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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3349
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pld1
Name: phospholipase D1
Acc ID: CHEBI:28885
Term: butan-1-ol
Definition: A primary alcohol that is butane in which a hydrogen of one of the methyl groups is substituted by a hydroxy group. It it produced in small amounts in humans by the gut microbes.
Chemical ID: MESH:D020001
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pld1decreases activityEXP 6480464CTD1-Butanol results in decreased activity of PLD1 proteinPMID:15652502 PMID:18344600
Pld1multiple interactionsEXP 6480464CTD1-Butanol inhibits the reaction [PLD1 protein affects the reaction [lysophosphatidic acid results in increased phosphorylation of MAPK1 protein]]; 1-Butanol inhibits the reaction [PLD1 protein affects the reaction [lysophosphatidic acid results in increased phosphorylation of MAPK3 protein]]; [1-Butanol inhibits the reaction [PRKCA protein binds to PLD1 protein]] which results in decreased activity of PLD1 proteinPMID:11243883 PMID:15652502
Pld1decreases activityISOPld1 (Mus musculus)6480464CTD1-Butanol results in decreased activity of PLD1 proteinPMID:19284563
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