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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737155
Species: Homo sapiens
RGD Object: Gene
Symbol: FOXO1
Name: forkhead box O1
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
FOXO1decreases expressionEXP 6480464CTDCisplatin results in decreased expression of FOXO1 mRNAPMID:27392435
FOXO1multiple interactionsEXP 6480464CTD[Cisplatin co-treated with Arsenic Trioxide] results in decreased phosphorylation of FOXO1 proteinPMID:29944906
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