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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735672
Species: Mus musculus
RGD Object: Gene
Symbol: Pecr
Name: peroxisomal trans-2-enoyl-CoA reductase
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pecrdecreases expressionEXP 6480464CTDCisplatin results in decreased expression of PECR mRNAPMID:24280081 PMID:35367536
Pecrmultiple interactionsEXP 6480464CTDMelatonin inhibits the reaction [Cisplatin results in decreased expression of PECR mRNA]PMID:35367536
Pecrdecreases expressionISOPECR (Homo sapiens)6480464CTDCisplatin results in decreased expression of PECR mRNAPMID:24280081
Pecrdecreases expressionISOPecr (Rattus norvegicus)6480464CTDCisplatin results in decreased expression of PECR mRNAPMID:36006825
Pecrmultiple interactionsISOPecr (Rattus norvegicus)6480464CTDMelatonin inhibits the reaction [Cisplatin results in decreased expression of PECR mRNA]PMID:36006825
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