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ONTOLOGY REPORT - ANNOTATIONS


Term:cisplatin
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Accession:CHEBI:27899 term browser browse the term
Definition:A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Synonyms:exact_synonym: (SP-4-2)-diamminedichloridoplatinum;   (SP-4-2)-diamminedichloroplatinum;   cis-diamminedichloridoplatinum(II)
 related_synonym: Briplatin;   CDDP;   Cismaplat;   Formula=Cl2H6N2Pt;   Formula=H6Cl2N2Pt;   InChI=1S/2ClH.2H3N.Pt/h2*1H;2*1H3;/q;;;;+2/p-2;   InChIKey=LXZZYRPGZAFOLE-UHFFFAOYSA-L;   Lederplatin;   Neoplatin;   Peyrone's chloride;   Peyrone's salt;   Platamine;   Platinex;   Platinol;   Randa;   SMILES=[H][N]([H])([H])[Pt](Cl)(Cl)[N]([H])([H])[H];   [PtCl2(NH3)2];   cis-DDP;   cis-Diamminedichloroplatinum(II);   cis-[PtCl2(NH3)2];   cis-diamminedichloroplatinum;   cis-diammineplatinum(II) dichloride;   cis-dichlorodiammineplatinum(II);   cis-platin;   cisplatine;   cisplatino;   cisplatinum
 alt_id: CHEBI:23314;   CHEBI:3722
 xref: CAS:15663-27-1 "ChemIDplus";   CAS:15663-27-1 "KEGG COMPOUND";   DrugBank:DB00515;   Gmelin:2519 "Gmelin";   HMDB:HMDB0014656;   KEGG:C06911;   KEGG:D00275
 xref_mesh: MESH:D002945
 xref: MetaCyc:CPD0-1392;   MolBase:25;   PMID:10883661 "Europe PMC";   PMID:12537968 "Europe PMC";   PMID:12831510 "Europe PMC";   PMID:12935404 "Europe PMC";   PMID:16327988 "Europe PMC";   PMID:18472761 "Europe PMC";   PMID:1855275 "Europe PMC";   PMID:23554447 "Europe PMC";   PMID:23604226 "Europe PMC";   PMID:23651576 "Europe PMC";   Patent:DE2318020;   Patent:DE2329485;   Reaxys:11324567 "Reaxys";   Wikipedia:Cisplatin


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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21038
    role 21018
      application 20451
        reagent 17645
          cross-linking reagent 7477
            cisplatin 7437
Path 2
Term Annotations click to browse term
  CHEBI ontology 21038
    subatomic particle 21032
      composite particle 21032
        hadron 21032
          baryon 21032
            nucleon 21032
              atomic nucleus 21032
                atom 21032
                  metal atom 18036
                    transition element atom 17486
                      d-block element atom 17472
                        nickel group element atom 10272
                          platinum 8515
                            platinum molecular entity 8515
                              platinum coordination entity 8515
                                diamminedichloroplatinum 7437
                                  cisplatin 7437
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