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RGD ID: 1562269
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nod1
Name: nucleotide-binding oligomerization domain containing 1
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nod1affects expressionISONOD1 (Homo sapiens)6480464CTDCisplatin affects the expression of NOD1 mRNAPMID:23300844
Nod1increases expressionISONOD1 (Homo sapiens)6480464CTDCisplatin results in increased expression of NOD1 mRNA; Cisplatin results in increased expression of NOD1 proteinPMID:21278888
Nod1increases expressionISONod1 (Mus musculus)6480464CTDCisplatin results in increased expression of NOD1 mRNAPMID:21151649
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