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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1354090
Species: Homo sapiens
RGD Object: Gene
Symbol: EIF2AK3
Name: eukaryotic translation initiation factor 2 alpha kinase 3
Acc ID: CHEBI:27214
Term: uranium atom
Definition: An actinoid atom that has formula U.
Chemical ID: MESH:D014501
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
EIF2AK3increases expressionISOEif2ak3 (Rattus norvegicus)6480464CTDUranium results in increased expression of EIF2AK3 mRNA; Uranium results in increased expression of EIF2AK3 proteinPMID:37270086
EIF2AK3multiple interactionsISOEif2ak3 (Rattus norvegicus)6480464CTDEIF2AK3 protein promotes the reaction [Uranium results in increased expression of CASP3 protein]; EIF2AK3 protein promotes the reaction [Uranium results in increased expression of DDIT3 protein]; THBS1 protein inhibits the reaction [Uranium results in increased expression of EIF2AK3 mRNA]; THBS1 protein inhibits the reaction [Uranium results in increased expression of EIF2AK3 protein]PMID:37270086
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