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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737353
Species: Homo sapiens
RGD Object: Gene
Symbol: MME
Name: membrane metalloendopeptidase
Acc ID: CHEBI:17634
Term: D-glucose
Definition: A glucose with D-configuration.
Chemical ID: MESH:D005947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MMEdecreases expressionISOMme (Mus musculus)6480464CTDGlucose results in decreased expression of MME mRNAPMID:17178593
MMEmultiple interactionsISOMme (Mus musculus)6480464CTD[MME protein results in increased cleavage of angiotensin I (1-7)] affects the reaction [Glucose results in increased secretion of INS1 protein]; MME protein affects the reaction [angiotensin I (1-7) promotes the reaction [Glucose results in increased secretion of INS1 protein]]PMID:28559246
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