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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731073
Species: Mus musculus
RGD Object: Gene
Symbol: Vegfa
Name: vascular endothelial growth factor A
Acc ID: CHEBI:17276
Term: phloretin
Definition: A member of the class of dihydrochalcones that is dihydrochalcone substituted by hydroxy groups at positions 4, 2', 4' and 6'.
Chemical ID: MESH:D010693
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vegfamultiple interactionsEXP 6480464CTD2,2-bis(4-glycidyloxyphenyl)propane affects the reaction [[cobaltous chloride co-treated with lipopolysaccharide, E coli O55-B5 co-treated with Phloretin] results in increased expression of VEGFA mRNA]; 2,2-bis(4-glycidyloxyphenyl)propane affects the reaction [[cobaltous chloride co-treated with Phloretin] affects the expression of VEGFA mRNA]; 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Phloretin promotes the reaction [[cobaltous chloride co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of VEGFA protein]]; [cobaltous chloride co-treated with lipopolysaccharide, E coli O55-B5 co-treated with Phloretin] results in increased expression of VEGFA mRNA; [cobaltous chloride co-treated with Phloretin] affects the expression of VEGFA mRNA; Phloretin promotes the reaction [[cobaltous chloride co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of VEGFA protein]PMID:32408695
Vegfamultiple interactionsISOVEGFA (Homo sapiens)6480464CTD[Ruthenium binds to Phloretin] which results in decreased expression of VEGFA proteinPMID:34896434
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