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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620436
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cga
Name: glycoprotein hormones, alpha polypeptide
Acc ID: CHEBI:17026
Term: progesterone
Definition: A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Chemical ID: MESH:D011374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cgaincreases abundanceEXP 6480464CTDCGA protein results in increased abundance of ProgesteronePMID:21458522 PMID:21871944
Cgaincreases secretionEXP 6480464CTDCGA protein results in increased secretion of ProgesteronePMID:18401014
Cgamultiple interactionsEXP 6480464CTD[[3,4',5-trimethoxystilbene co-treated with CGA protein] results in decreased expression of CYP17A1 protein] which results in increased secretion of Progesterone; [[resveratrol analog co-treated with CGA protein] results in decreased expression of CYP17A1 protein] which results in increased secretion of Progesterone; [[resveratrol co-treated with CGA protein] results in decreased expression of CYP17A1 protein] which results in increased secretion of Progesterone; ADM protein inhibits the reaction [CGA protein results in increased secretion of Progesterone]; bifenthrin analog inhibits the reaction [CGA protein results in increased abundance of Progesterone]PMID:18401014 PMID:19603415 PMID:21871944
Cgaincreases abundanceISOCga (Mus musculus)6480464CTDCGA protein results in increased abundance of ProgesteronePMID:11213355 PMID:12647776 PMID:27181934
Cgaincreases secretionISOCGA (Homo sapiens)6480464CTDCGA protein results in increased secretion of ProgesteronePMID:19228890 PMID:20610540 PMID:25016925 PMID:29366778 PMID:31132478 PMID:33638691
Cgamultiple interactionsISOCGA (Homo sapiens)6480464CTD[3,4',5-trimethoxystilbene co-treated with CGA protein] results in increased secretion of Progesterone; [CGA protein affects the secretion of Cyclic AMP] which results in increased secretion of Progesterone; [CGA protein co-treated with FSHB protein] results in increased abundance of Progesterone; [CGA protein co-treated with FSHB protein] results in increased secretion of Progesterone; [Resveratrol analog co-treated with CGA protein] results in increased secretion of Progesterone; [Resveratrol co-treated with CGA protein] results in increased secretion of Progesterone; [T0901317 co-treated with fatostatin] promotes the reaction [CGA protein results in increased secretion of Progesterone]; ADM protein modified form inhibits the reaction [ADM protein inhibits the reaction [CGA protein results in increased secretion of Progesterone]]; butylbenzyl phthalate inhibits the reaction [CGA protein results in increased secretion of Progesterone]; CFL1 protein affects the reaction [CGA protein results in increased secretion of Progesterone]; DDT inhibits the reaction [CGA protein results in increased secretion of Progesterone]; decabromobiphenyl ether inhibits the reaction [CGA protein results in increased secretion of Progesterone]; Dibutyl Phthalate inhibits the reaction [CGA protein results in increased secretion of Progesterone]; Diethylhexyl Phthalate inhibits the reaction [CGA protein results in increased secretion of Progesterone]; fatostatin promotes the reaction [CGA protein results in increased secretion of Progesterone]; T0901317 inhibits the reaction [[CGA protein co-treated with FSHB protein] results in increased abundance of Progesterone]PMID:18401014 PMID:19228890 PMID:19603415 PMID:20610540 PMID:20926582 PMID:23071612 PMID:25016925 PMID:29366778 PMID:31132478 PMID:33638691
Cgamultiple interactionsISOCga (Mus musculus)6480464CTDlead acetate inhibits the reaction [CGA protein results in increased abundance of Progesterone]; mono-(2-ethylhexyl)phthalate inhibits the reaction [CGA protein results in increased abundance of Progesterone]PMID:11213355 PMID:12647776 PMID:27181934
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