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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1307471
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp39a1
Name: cytochrome P450, family 39, subfamily a, polypeptide 1
Acc ID: CHEBI:16325
Term: lithocholic acid
Definition: A monohydroxy-5beta-cholanic acid with a alpha-hydroxy substituent at position 3. It is a bile acid obtained from chenodeoxycholic acid by bacterial action.
Chemical ID: MESH:D008095
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp39a1multiple interactionsISOCyp39a1 (Mus musculus)6480464CTD[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Lithocholic Acid] results in increased expression of CYP39A1 mRNA; [Phenobarbital co-treated with Lithocholic Acid] results in increased expression of CYP39A1 mRNA; NR1I3 protein promotes the reaction [[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Lithocholic Acid] results in increased expression of CYP39A1 mRNA]; NR1I3 protein promotes the reaction [[Phenobarbital co-treated with Lithocholic Acid] results in increased expression of CYP39A1 mRNA]PMID:19196849
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