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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731867
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp2a5
Name: cytochrome P450, family 2, subfamily a, polypeptide 5
Acc ID: CHEBI:142921
Term: 3-phenylprop-2-enal
Definition: A member of the class of cinnamaldehydes that is prop-2-enal in which a hydrogen at position 3 has been replaced by a phenyl group. The configuration of the double bond is not specified; the name 'cinnamaldehyde' is widely used to refer to the E (trans) isomer.
Chemical ID: MESH:C012843
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2a5decreases activityISOCYP2A6 (Homo sapiens)6480464CTDcinnamaldehyde results in decreased activity of CYP2A6 proteinPMID:32496054
Cyp2a5multiple interactionsISOCYP2A6 (Homo sapiens)6480464CTD[[cinnamaldehyde results in decreased activity of CYP2A6 protein] which results in decreased hydroxylation of 3-cyanocoumarin] which results in decreased chemical synthesis of 3-cyano-7-hydroxycoumarin; [cinnamaldehyde results in decreased activity of CYP2A6 protein] which results in decreased hydroxylation of 3-cyanocoumarinPMID:32496054
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