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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68364
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sigmar1
Name: sigma non-opioid intracellular receptor 1
Acc ID: CHEBI:140905
Term: N-\{2-[4-methoxy-3-(2-phenylethoxy)phenyl]ethyl\}-N-propylpropan-1-amine hydrochloride
Definition: An aromatic ether that is (2-phenoxyethyl)benzene which carries a 2-(dipropylamino)ethyl group at position 3 and a methoxy group at position 6. It is a potent and selective sigma1 receptor antagonist.
Chemical ID: MESH:C083832
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sigmar1multiple interactionsEXP 6480464CTD[N,N-dipropyl-2-(4-methoxy-3-(2-phenylethoxy)phenyl)ethylamine monohydrochloride binds to and results in decreased activity of SIGMAR1 protein] inhibits the reaction [1-(3-(4-(3-chlorophenyl)-1-piperazinyl)propyl)-3,4-dihydro-5-methoxy-2(1H)-quinolinone results in increased secretion of Acetylcholine]PMID:11907181
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