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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62229
Species: Mus musculus
RGD Object: Gene
Symbol: Slc22a2
Name: solute carrier family 22 (organic cation transporter), member 2
Acc ID: CHEBI:138885
Term: prinomastat
Definition: A hydroxamic acid that is (3S)-N-hydroxy-2,2-dimethylthiomorpholine-3-carboxamide in which the hydrogen attached to the thiomorpholine nitrogen has been replaced by a [4-(pyridin-4-yloxy)phenyl]sulfonyl group. It is a selective inhibitor with of matrix metalloproteinases (MMPs) 2, 3, 9, 13, and 14.
Chemical ID: MESH:C113282
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc22a2multiple interactionsISOSLC22A2 (Homo sapiens)6480464CTDprinomastat inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]PMID:21599003
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