Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737579
Species: Mus musculus
RGD Object: Gene
Symbol: Slc11a2
Name: solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
Acc ID: CHEBI:63041
Term: manganese(II) chloride
Definition: An inorganic chloride in which manganese(II) is coordinated to two chloride ions. In its anhydrous state manganese(II) chloride is a polymeric solid, which adopts a layered cadmium chloride-like structure.
Chemical ID: MESH:C025340
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc11a2increases expressionEXP 6480464CTDmanganese chloride results in increased expression of SLC11A2 mRNAPMID:22465424
Slc11a2multiple interactionsEXP 6480464CTD[manganese chloride results in increased abundance of Manganese] which results in increased expression of SLC11A2 mRNA; SLC11A2 protein affects the reaction [manganese chloride results in increased uptake of Copper]PMID:22465424 PMID:34590183
Slc11a2affects expressionISOSlc11a2 (Rattus norvegicus)6480464CTDmanganese chloride affects the expression of SLC11A2 mRNAPMID:20635692
Slc11a2decreases uptakeISOSlc11a2 (Rattus norvegicus)6480464CTDSLC11A2 protein mutant form results in decreased uptake of manganese chloridePMID:17116743
Slc11a2increases expressionISOSlc11a2 (Rattus norvegicus)6480464CTDmanganese chloride results in increased expression of SLC11A2 mRNA; manganese chloride results in increased expression of SLC11A2 proteinPMID:25575534
Slc11a2increases expressionISOSLC11A2 (Homo sapiens)6480464CTDmanganese chloride results in increased expression of SLC11A2 mRNAPMID:17175027
Slc11a2increases transportISOSLC11A2 (Homo sapiens)6480464CTDSLC11A2 protein results in increased transport of manganese chloridePMID:22736759
Slc11a2multiple interactionsISOSlc11a2 (Rattus norvegicus)6480464CTD[[manganese chloride results in increased expression of SLC11A2 protein] which results in increased abundance of Manganese] which affects the abundance of Copper; [manganese chloride results in increased expression of SLC11A2 protein] which results in increased abundance of Manganese; Iron inhibits the reaction [SLC11A2 protein results in increased uptake of manganese chloride]PMID:17116743 PMID:25575534
Go Back to source page   Continue to Ontology report