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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737539
Species: Homo sapiens
RGD Object: Gene
Symbol: FKBP1A
Name: FKBP prolyl isomerase 1A
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
FKBP1Aaffects methylationEXP 6480464CTDBenzo(a)pyrene affects the methylation of FKBP1A intronPMID:30157460
FKBP1Adecreases methylationEXP 6480464CTDBenzo(a)pyrene results in decreased methylation of FKBP1A promoterPMID:27901495
FKBP1Adecreases expressionISOFkbp1a (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of FKBP1A mRNAPMID:19770486
FKBP1Aincreases expressionISOFkbp1a (Rattus norvegicus)6480464CTDBenzo(a)pyrene results in increased expression of FKBP1A mRNAPMID:21839799
FKBP1Amultiple interactionsISOFkbp1a (Mus musculus)6480464CTD[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of FKBP1A mRNAPMID:27858113
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